Dr. Ray Wisniewski, Founder & CEO of NutriMost Wellness & Weight Loss reviews the latest research on Fatty Liver Disease. A new study in Cell Metabolism describes a new and previously unknown molecular mechanism to reduce fatty liver using a low carbohydrate diet. Previously it was thought that a low calorie diet must be included to reduce fatty liver.
NutriMost Reviews Fatty Liver Research
Fatty Liver or NASH, (nonalcoholic steatohepatitis), is an excess accumulation of fat in the liver. Fatty Liver is a fairly common condition affecting over 20% of Americans and about 75% of obese Americans although most are asymptomatic and discover the condition on routine testing. The 2 most common blood tests which are elevated with Fatty Liver are the liver enzymes ALT and AST. It may also be seen on Ultrasound and confirmed using biopsy.
Fatty Liver occurs when the amount of Fatty Acids and the synthesis of fatty acids exceed the oxidation and secretion of fatty acids. The process of the conversion of triglycerides to free fatty acids as well as PPAR (peroxisome proliferator-activated receptors); especially the role of PPAR-α and PPAR-γ.
PPAR-α is known to increase fatty acid oxidation when there is excess fat, while PPAR-γ decreases fatty acid oxidation.
A new study in Cell Metabolism by researchers from KTH, University of Gothenburg along with other collaborative researchers describes a new and previously unknown molecular mechanism to reduce fatty liver.
It has always been thought that the only way to affect Fatty Liver was through Weight Loss, such as the NutriMost Weight Loss program. This new study showed dramatic changes in the liver fat without affecting weight loss by not reducing calories but by restricting carbohydrates and increasing protein. The diet appeared to affect the microbiome, and increased the folate-dependent one-carbon metabolism gene expression in the liver. It appears that by increasing the one-carbon metabolism gene expression (the methylation pathway), increased fatty acid oxidation.
Dr. Wisniewski reviews an understanding of how fatty liver may actually be protective against hepatotoxicity and how in practice, the NutriMost Weight Loss program works to implement research such as this to optimize the results.
An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans. Cell Metabolism, 2018; DOI: 10.1016/j.cmet.2018.01.005
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